Experimental Neurosurgery, Department of Neurosurgery
Frankfurt University Hospital
D-60528 Frankfurt am Main
Tel ++49 69-6301-6923
Fax ++49 69- 6301-5575
Our research mainly focuses on the molecular mechanisms of apoptosis, non-apoptotic cell death and autophagy. We are elucidating the molecular events leading to gliomagenesis, as well as apoptosis deficiency and therapy resistance of glioblastoma (GBM), the most malignant and deadly human primary brain tumor. Based on these investigations, we are trying to develop novel genetic insight-based therapeutic strategies for the treatment of gliomas in cell culture models and in transplantable syngeneic animal tumor models. One recent example is our finding that the natural anticancer drug AT-101 triggers an excessive, cell-lethal type of mitophagy - the selective removal of mitochondria via the autophagosomal/lysosomal pathway [ pubmed.ncbi.nlm.nih.gov/29938581/ ].
Furthermore recent research of our lab focuses on the mechanisms regulating the stem-like state of glioma cells and on genetic and pharmacological approaches to prevent and inhibit this phenotype.