Influence of human cytomegalovirus on tumor progression
Infection with human cytomegalovirus (HCMV) is very common in the population. Although the virus does not possess ability to transform normal cells (like classical tumor viruses), infection of already existing tumor cells with HCMV can increase the malignancy of the tumor (so called oncomodulation). Simultaneously, the efficacy of chemotherapeutic drugs is strongly decreased.
In our lab, we investigate the effects of HCMV infection and specific viral genes of HCMV on proliferation, cell cycle, apoptosis and angiogenesis of the tumor cells. It is possible that oncomodulatory effects are also excerted by viruses other than HCMV. Understanding the mechanisms that lead to oncomodulation is crucial for the development of new anti-tumor therapies, using combination of antiviral and antitumoral drugs.
We have developed cell culture models of respiratory viruses and herpes viruses which enable us to test different substances for their antiviral potency. This tool helped us to identify novel subst