AG Radeke

Figure 1. Projects of the group are centered around the role of dendritic and T cells in chronic inflammation and cancerogenesis (click on project items for details).

Introduction

Infiltrates of mononuclear cells represent the hallmark of chronic inflammation. Following tissue injury cells of the innate and adaptive immune system invade the respective tissue through their interaction with adhesion molecules and chemotactic factors, such as bacterial components, lipids, complement fragments and chemokines. Different from acute inflammation, chronic inflammation is specifically characterized by repetitive and non-healing injury based on genetic, environmental immune deviating predisposition, and by pathological homing of immune cells finally leading to tertiary lymphoid structures as major drivers of chronicity. The interaction of the injurious agent and local cells with the professional immune system will have a decisive influence on the transition from acute to chronic inflammation, a process finally destroying vital organ function. Chronic inflammatory processes always include futile repair processes including cell protective mechanisms that eventually will support a cancerogenic transformation. Our research int