Publikationen 2020

  1. Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. S1P d20:1, an endogenous modulator of S1P d18:1/S1P(2) -dependent signaling. FASEB J., 2020 (in press)

  2. Meschede J, Šadić M, Furthmann N, Miedema T, Sehr DA, Müller-Rischart AK, Bader V, Berlemann LA, Pilsl A, Schlierf A, Barkovits K, Kachholz B, Rittinger K, Ikeda F, Marcus K, Schaefer L, Tatzelt J, Winklhofer KF. The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC. Sci Signal., 13(617), 2020

  3. Roedig H, Damiescu R, Zeng-Brouwers J, Kutija I, Trebicka J, Wygrecka M, Schaefer L. Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development. Semin Cancer Biol, 62: 31-47, 2020

  4. Monteiro S, Grandt J, Uschner F, Kimer N, Madson JL, Schierwagen R, Klein S, Welsch C, Schaefer L, Jansen C, Claria J, Alceraz-Quiles J, Arroyo V, Moreau R, Fernandez J, Bendsen F, Mehta G, Gluud LL, Moller S, Praktiknjo M, Trebicka J. Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation. Gut, 2020 (in press)

  5. Wygrecka M and Schaefer L. Between life and death: Epithelial cells in lung pathologies. Cell Signal doi.org/10.1016/j.cellsig.2020.109652, 2020

  6. Rudloff I, Jarde T, Bachmann M, Elgass KD, Kerr G, Engel R, Richards E, Oliva K, Wilkins S, McMurrick PJ, Abud HE, Mühl H, Nold MF. Molecular signature of interleukin-22 in colon carcinoma cells and organoid models. Transl Res., 216: 1-22, 2020

  7. Thati M, Ghosh S, Wang H, Wie D, Gupta D, Stoyanov S, Elwakiel A, Al-Dabet MM, Krishnan S, Kohli S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi IUR, Rana R, Zeng-Brouwers J, Möller M, Schaefer L, Esmon C, Reiser J, Rezaie A, Ruf W, Isermann B. Integrin αvβ3 on podocytes orchestrates coagulation protease signaling through protease-activated receptors. J Am Soc Nephrol., 2020 (in press)

  8. Zeng-Brouwers J, Pandey S, Trebicka J, Wygrecka M, Schaefer L. Communications via the small leucine-rich proteoglycans: Molecular specificity in inflammation and autoimmune diseases. J Histochem Cytochem., 2020  (in press)

  9. Schierwagen R, Uschner FE, Torres S, Ortiz C, Brol MJ, Tyc O, Gu W, Grimm C, Zeuzem S, Plamper A, Pfeifer P, Zimmer S, Welsch C, Schaefer L, Rheinwalt KP, Clària J, Arroyo V, Trebicka J, Klein S. The role of macrophage-inducible C-type lectin in different stages of chronic liver disease. Front Immunol., 2020 (in press)

  10. Schwarzkopf KM, Eberle L, Uschner FE, Klein S, Schierwagen R, Muecke MM, Schaefer L, Clària J, Zeuzem S, Hintermann E, Christen U, Lange CM, Trebicka J, Welsch C: Interleukin-22 (IL-22) in Acute-on-Chronic Liver Failure. A matter of ineffective levels, receptor dysregulation or defective signaling? J Hepatol., 2020 (in press)

  11. Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Mühl H. A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury. J Cell Mol Med., 2020 (in press)

  12. Jakobi K, Beyer S, Koch A, Thomas D, Schwalm S, Zeuzem S, Pfeilschifter J, Grammatikos G. Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro. Int J Mol Sci., 21(7): 2409, 2020

Publikationen 2019

  1. Zucker M, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M. LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension. Biochim Biophys Acta - Mol Basis Dis, 1865:1604-1616, 2019

  2. Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LTH, Brandts C, Fulda S, Wygrecka M, and Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol., 77, 4-22, 2019

  3. Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Muench C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L: Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury.  Kidney Int., 95: 540-562, 2019

  4. Christen U. Pathogen infection and autoimmune disease. Clin Exp Immunol., 195(1): 10-14, 2019

  5. Christen U and Hintermann E. Pathogens and autoimmune hepatitis. Clin Exp Immunol., 195(1): 35-51, 2019

  6. Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Cell, 176(6): 1407-1419, 2019

  7. Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J., 33(2): 1711-1726, 2019

  8. Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids, 1864(3): 304-311, 2019

  9. Violatto MB, Casarin E, Talamini L, Russo L, Baldan S, Tondello C, Messmer M, Hintermann E, Rossi A, Passoni A, Bagnati R, Biffi S, Toffanin C, Gimondi S, Fumagalli S, De Simoni MG, Barisani D, Salmona M, Christen U, Invernizzi P, Bigini P, Morpurgo M. Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model. ACS Nano, 13(4): 4410-4423, 2019

  10. Roedig H, Nastase MV, Wygrecka M, Schaefer L. Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J., 286(15): 2965-2979, 2019

  11. Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene, 38(24): 4788-4803, 2019

  12. Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S. Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. Nitric Oxide, 87: 31-42, 2019

  13. Büttner S, Koch A, Pfeilschifter J. Diuretic Therapy. Dtsch Med Wochenschr., 144(6): 387-392, German, 2019

  14. Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M. Lipi