Publikationen 2020

  1. Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. S1P d20:1, an endogenous modulator of S1P d18:1/S1P(2) -dependent signaling. FASEB J., 2020 (in press)

  2. Meschede J, Šadić M, Furthmann N, Miedema T, Sehr DA, Müller-Rischart AK, Bader V, Berlemann LA, Pilsl A, Schlierf A, Barkovits K, Kachholz B, Rittinger K, Ikeda F, Marcus K, Schaefer L, Tatzelt J, Winklhofer KF. The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC. Sci Signal., 13(617), 2020

  3. Roedig H, Damiescu R, Zeng-Brouwers J, Kutija I, Trebicka J, Wygrecka M, Schaefer L. Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development. Semin Cancer Biol, 62: 31-47, 2020

  4. Monteiro S, Grandt J, Uschner F, Kimer N, Madson JL, Schierwagen R, Klein S, Welsch C, Schaefer L, Jansen C, Claria J, Alceraz-Quiles J, Arroyo V, Moreau R, Fernandez J, Bendsen F, Mehta G, Gluud LL, Moller S, Praktiknjo M, Trebicka J. Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation. Gut, 2020 (in press)

  5. Wygrecka M and Schaefer L. Between life and death: Epithelial cells in lung pathologies. Cell Signal, 2020

  6. Rudloff I, Jarde T, Bachmann M, Elgass KD, Kerr G, Engel R, Richards E, Oliva K, Wilkins S, McMurrick PJ, Abud HE, Mühl H, Nold MF. Molecular signature of interleukin-22 in colon carcinoma cells and organoid models. Transl Res., 216: 1-22, 2020

  7. Thati M, Ghosh S, Wang H, Wie D, Gupta D, Stoyanov S, Elwakiel A, Al-Dabet MM, Krishnan S, Kohli S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi IUR, Rana R, Zeng-Brouwers J, Möller M, Schaefer L, Esmon C, Reiser J, Rezaie A, Ruf W, Isermann B. Integrin αvβ3 on podocytes orchestrates coagulation protease signaling through protease-activated receptors. J Am Soc Nephrol., 2020 (in press)

  8. Zeng-Brouwers J, Pandey S, Trebicka J, Wygrecka M, Schaefer L. Communications via the small leucine-rich proteoglycans: Molecular specificity in inflammation and autoimmune diseases. J Histochem Cytochem., 2020  (in press)

  9. Schierwagen R, Uschner FE, Torres S, Ortiz C, Brol MJ, Tyc O, Gu W, Grimm C, Zeuzem S, Plamper A, Pfeifer P, Zimmer S, Welsch C, Schaefer L, Rheinwalt KP, Clària J, Arroyo V, Trebicka J, Klein S. The role of macrophage-inducible C-type lectin in different stages of chronic liver disease. Front Immunol., 2020 (in press)

  10. Schwarzkopf KM, Eberle L, Uschner FE, Klein S, Schierwagen R, Muecke MM, Schaefer L, Clària J, Zeuzem S, Hintermann E, Christen U, Lange CM, Trebicka J, Welsch C: Interleukin-22 (IL-22) in Acute-on-Chronic Liver Failure. A matter of ineffective levels, receptor dysregulation or defective signaling? J Hepatol., 2020 (in press)

  11. Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Mühl H. A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury. J Cell Mol Med., 2020 (in press)

Publikationen 2019

  1. Zucker M, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M. LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension. Biochim Biophys Acta - Mol Basis Dis, 1865:1604-1616, 2019

  2. Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LTH, Brandts C, Fulda S, Wygrecka M, and Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol., 77, 4-22, 2019

  3. Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Muench C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L: Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury.  Kidney Int., 95: 540-562, 2019

  4. Christen U. Pathogen infection and autoimmune disease. Clin Exp Immunol., 195(1): 10-14, 2019

  5. Christen U and Hintermann E. Pathogens and autoimmune hepatitis. Clin Exp Immunol., 195(1): 35-51, 2019

  6. Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Cell, 176(6): 1407-1419, 2019

  7. Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J., 33(2): 1711-1726, 2019

  8. Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids, 1864(3): 304-311, 2019

  9. Violatto MB, Casarin E, Talamini L, Russo L, Baldan S, Tondello C, Messmer M, Hintermann E, Rossi A, Passoni A, Bagnati R, Biffi S, Toffanin C, Gimondi S, Fumagalli S, De Simoni MG, Barisani D, Salmona M, Christen U, Invernizzi P, Bigini P, Morpurgo M. Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model. ACS Nano, 13(4): 4410-4423, 2019

  10. Roedig H, Nastase MV, Wygrecka M, Schaefer L. Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J., 286(15): 2965-2979, 2019

  11. Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene, 38(24): 4788-4803, 2019

  12. Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S. Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. Nitric Oxide, 87: 31-42, 2019

  13. Büttner S, Koch A, Pfeilschifter J. Diuretic Therapy. Dtsch Med Wochenschr., 144(6): 387-392, German, 2019

  14. Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M. Lipids - two sides of the same coin in lung fibrosis.Cell Signal, 60: 65-80, 2019

  15. Christen U. Animal models of autoimmune hepatitis. Biochim Biophys Acta- Mol Bases Dis, 1865(5): 970-981, 2019

  16. Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol., 186: 130-135, 2019

  17. Didiasova M, Schaefer L, Wygrecka M. When place matters: shuttling of enolase-1 across cellular compartments.Front Cell Dev Biol., 26;7:61. doi: 10.3389/fcell.2019.00061. eCollection 2019.

  18. von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic  M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B. Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis. Theranostics, 16;9(7): 2003-2016, 2019

  19. Fuchs S, Bayer M, Taubert R, Manns MP, Pfeilschifter JM, Christen U, Hintermann E. Effects of adenovirus-induced hepatocyte damage on chronic bileduct inflammation in a sclerosing cholangitis mouse model.Liver Int. 2019 Jun 21. doi: 10.1111/liv.14183. [Epub ahead of print] PubMed PMID: 31225929.

  20. Mücke VT, Thomas D, Mücke MM, Waidmann O, Zeuzem S, Sarrazin C, Pfeilschifter J, Vermehren J, Finkelmeier F, Grammatikos G. Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response. Liver Int. 2019 Jun 17. doi: 10.1111/liv.14178. [Epub ahead of print] PubMed PMID: 31207039.

  21. Patyna S, Büttner S, Eckes T, Obermüller N, Bartel C, Braner A, Trautmann S, Thomas D, Geiger H, Pfeilschifter J, Koch A. Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus. Prostaglandins Other Lipid Mediat. 2019 Jul 10:106348. doi: 10.1016/j.prostaglandins.2019.106348. [Epub ahead of print] PubMed PMID: 31301404.

  22. Eberhardt W, Nasrullah U and Haeussler K. Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?Cells, 8, 797, 2019

  23. Mühl H, Bachmann M. IL-18/IL-18BP and IL-22/IL-22BP:Two interrelated couples with therapeutic potential.Cell Signal., Aug 8:109388. doi: 10.1016/j.cellsig.2019.109388. [Epub ahead of print], 2019

  24. Ghițu A, Schwiebs A, Radeke HH, Avram S, Zupko I, Bor A, Pavel IZ, DeheleanCA, Oprean C, Bojin F, Farcas C, Soica C, Duicu O, Danciu C. A ComprehensiveAssessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound. Nutrients, 16;11(4), 2019

  25. Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, Fuhrmann D, Petcherski A, Heringdorf DMZ, Radeke HH, Brüne B. Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation. Biochim Biophys Acta - Mol Cell Biol Lipids, 1864(9): 1235-1246, 2019

  26. Danciu C, Pinzaru I, Coricovac D, Andrica F, Sizemore I, Dehelean C, Baderca F, Lazureanu V, Soica C, Mioc M, Radeke H. Betulin silver nanoparticles qualify as efficient antimelanoma agents in in vitro and in vivo studies. Eur J Pharm Biopharm., 134: 1-19, 2019

  27. Dreis C, Ottenlinger FM, Putyrski M, Ernst A, Huhn M, Schmidt KG, Pfeilschifter JM, Radeke HH. Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T  Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs. Front Immunol., 10: 1698, 2019

  28. Hewitt SM, Schaefer L. Renal Fibrosis: Common Enemy of Many Origins. J Histochem Cytochem., 67(9): 621, 2019

  29. Krämer M, Markart P, Drakopanagiotakis F, Mamazhakypov A, Schaefer L, Didiasova M, Wygrecka M. Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system. Cell Signal. 2020 Jan;65:109432. doi:10.1016/j.cellsig.2019.109432. Epub 2019 Nov 3. PubMed PMID: 31693876.

  30. Schnieder J, Mamazhakypov A, Birnhuber A, Wilhelm J, Kwapiszewska G, Ruppert C, Markart P, Wujak L, Rubio K, Barreto G, Schaefer L, Wygrecka M. Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores. Matrix Biol. 2019 Dec 10. pii: S0945-053X(19)30399-3. doi: 10.1016/j.matbio.2019.12.001.

  31. Nasrullah U, Haeussler K, Biyanee A, Wittig I, Pfeilschifter J, Eberhardt W. Identification of TRIM25 as a negative regulator of caspase-2 translation reveals a novel target for sensitizing colon carcinoma cells to intrinsic apoptosis.Cells, 2019, 8(12), 1622

  32. Hintermann E, Christen U. The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis. Cells, 8(12). pii: E1503. doi: 10.3390/cells8121503, 2019

  33. Christen U. Breakdown of tolerance in autoimmune hepatitis: This time toxin beats virus. Immunol Lett., 2019 Dec 2. pii: S0165-2478(19)30602-9, 2019

  34. Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I. Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Athe