Publikationen der Klinik für Strahlentherapie und Onkologie

Hier finden Sie die Publikationen der Klinik für Strahlentherapie und Onkologie der letzten Jahre.

Publikationen 2019

Diefenhardt M, Hofheinz RD, Martin D, Beissbarth T, Arnold D, Hartmann A, von der Grün J, Grützmann R, Liersch T, Ströbel P, Grabenbauer GG,  Rieger M, Fietkau R, Graeven U, Weitz J, Folprecht G, Ghadimi M, Rödel F, Rödel C, Fokas E. Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial. Int J Cancer 2019; epub ahead of print (Pubmed-Link)

Hess J, Unger K, Maihoefer C, Schüttrumpf L, Wintergerst L, Heider T, Weber P, Marschner S, Braselmann H, Samaga D, Kuger S, Pflugradt U, Baumeister P, Walch A, Woischke C, Kirchner T, Werner M, Werner K, Baumann M, Budach V, Combs SE, Debus J, Grosu AL, Krause M, Linge A, Rödel C, Stuschke M, Zips D, Zitzelsberger HF, Ganswindt U, Henke M, Belka C. A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV-infection. Clin Cancer Res 2019;25:1505-1516. (Pubmed-Link).

Klement RJ, Abbasi-Senger N, Adebahr S, Alheid H ,Allgaeuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Eble MJ, Ernst I, Gerum S, Habermehl D, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl H, Klass ND, Krempien R, Lewitzki V, Lohaus F, Ostheimer C, Papachristofilou A, Petersen C, Rieber J, Schneider T, Schrade E, Semrau R, Wachter S, Wittig A, Guckenberger M, Andratschk A. The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases. BMC Cancer 2019;19:173 (Pubmed-Link)

Lang BM, Balermpas P, Bauer A, Blum A, Brölsch GF, Dirschka T, Follmann M, Frank J, Frerich B, Fritz K, Hauschild A, Heindl LM, Howaldt HP, Ihrler S, Kakkassery V, Klumpp B, Krause-Bergmann A, Löser C, Meissner M, Sachse MM, Schlaak M, Schön MP, Tischendorf L, Tronnier M, Vordermark D, Welzel J, Weichenthal M, Wiegand S, Kaufmann R, Grabbe S. S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 1: Epidemiology, Genetics and Diagnosis .J Dtsch Dermatol Ges 2019;17:94-103 (Pubmed-Link).

Linder B, Wehle A, Bonn F, Hehlgans S, Dikic I, Rödel F. Seifert V, Kögel D. Arsenic Trioxid and (-)-Gossypol synergistically target glioma stem-like cells via Inhibition of Hedgehog and Notch signaling. Cancers 2019:11:350 (Pubmed-Link)

Martin D, Rödel C, Fokas E. Chemoradiotherapy for anal cancer: are we as good as we think? Strahlenther Onkol 2019; epub ahead of print (Pubmed-Link).

Müller-Längle A, Lutz H, Hehlgans S, Rödel F, Rau K, Laube B. NMDA Receptor-mediated signaling pathways enhance radiation resistance, survival and migration in glioblastoma cells - a potential target for adjuvant radiotherapy. Cancers 2019;accepted (Pubmed-Link).

Montero A, Sabater S, Rödel F, Gaipl US, Ott OJ, Seegenschmiedt MH, Arenas M. Is it time to redefine the role of low-dose radiotherapy for benign disease? Ann Rheum Dis 2018 Comment, epub ahead of print (Pubmed-Link).

Ott OJ, Micke O, Mücke R, Niewald M, Rödel F, Schäfer U, Seegenschmiedt MH, Arenas M, Frey B, Gaipl US. Low-dose radiotherapy: Mayday, mayday, we've been hit! Strahlenther Onkol 2018; Editorial, epub ahead of print (Pubmed-Link).

Raab M, Sanhaji M, Zhou S, Rödel F, El-Balat A, Becker S, Strebhardt K. Blocking mitotic exit of ovarian cancer cells by pharmaceutical inhibition of the Anaphase-Promoting Complex reduces chromosomal instability. Neoplasia 2019;21:363-375 (Pubmed-Link).

Rödel F, Martin D, Balermpas P, Wieland U, Winkelmann R, Riekmann T, Falk S, Rödel C, Fokas E. Modulation of radiation sensitivity and antitumor immunity by viral pathogenic factors: Implications for radio-immunotherapy. Biochim Biophys Acta Rev Cancer  2019;1871:126-137 (Pubmed-Link).

Stera S, Balermpas P, Blanck O, Wolff R, Wurster S, Baumann R, Szücs M, Loutfi-Krauss B, Wilhelm MS, Seifert V, Rades D, Rödel C, Dunst J, Hildebrandtg,  Arnold, A, Meissner M, Kähler, KC. Stereotactic radiosurgery combined with immune checkpoint inhibitors or kinase inhibitors for patients with multiple brain metastases of malignant melanoma. Melanoma Research2019;29:187-195 (Pubmed-Link).

Von der Grün J, Köhn J, Loutfi-Krauss B, Blanck O, Rödel C, Balermpas P. Second infield re-irradiation with a resulting cumulative equivalent dose (EQD2max ) of >180 Gy for patients with recurrent head and neck cancer. Head Neck 2019;41:E48-E54. (Pubmed-Link).

Von der Grün J, Winkelmann R, Meissner  M, Wieland U, Silling S, Martin D, Fokas E, Rödel C, Rödel F, Balermpas P. Merkel cell polyoma viral load and CD8+ lymphocyte infiltration predict overall survival in patients with Merkel cell carcinoma. Front Oncol 2019;9:20. (Pubmed-Link).

Von der Grün J, Rödel F, Fokas E, Guckenberger M, Rödel C, Brandts C, Balermpas P. Targeted therapies and immune-checkpoint inhibition in head and neck squamous cell carcinoma: Where do we stand and where to go. Cancers 2019;11:472. (Pubmed-Link).

Voss M, Franz K, Steinbach JP, Fokas E, Forster MT, Filipski K, Hattingen E, Wagner M, Breuer S.Contrast enhancing spots as a new pattern of late onset pseudoprogression in glioma patients. J Neurooncol 2019;142:161-169. (Pubmed-Link).

Wunderlich R, Rühle P, Deloch L, Rödel F, Fietkau R, Gaipl U, Frey B. Ionizing radiation reduces the capacity of activated macrophages to induce T-cell proliferation, but does not trigger dendritic cell-mediated non targeted effects. Int J Radiation Biol 2019;95:33-43. (Pubmed-Link).

2018

Balermpas P, Stera S, Müller von der Grün J, Loutfi-Krauss B, Forster MT, Wagner M, Keller C, Rödel C, Seifert V, Blanck O, Wolff R. Repeated in-field radiosurgery for locally recurrent brain metastases: Feasibility, results and survival in a heavily treated patient cohort. PLoS One 2018;13:e0198692 (Pubmed-Link).

Baumann R, Chan MKH, Pyschny F, Stera S, Malzkuhn B, Wurster S, Huttenlocher S, Szücs M, Imhoff D, Keller C, Balermpas P, Rades D, Rödel C, Dunst J, Hildebrandt G and Blanck O. Clinical Results of Mean GTV Dose Optimized Robotic-Guided Stereotactic Body Radiation Therapy for Lung Tumors. Front. Oncol 2018;8:171. (Pubmed-Link).

Chatzikonstantinou G, Zamboglou N, Archavlis E, Strouthos I, Zoga E, Milickovic N, Hilaris B, Baltas D, Rödel C, Tselis N. CT-guided interstitial HDR-brachytherapy for recurrent glioblastoma multiforme: a 20-year single-institute experience. Strahlenther Onkol 2018 ;194:1171-1179 (Pubmed-Link).

Combs SE, Niyazi M, Adeberg S, Bougatf N, Kaul D, Fleischmann DF, Gruen A, Fokas E, Rödel CM, Eckert F, Paulsen F, Oehlke O, Grosu AL, Seidlitz A, Lattermann A, Krause M, Baumann M, Guberina M, Stuschke M, Budach V, Belka C, Debus J, Kessel KA. Re-irradiation of recurrent gliomas: pooled analysis and validation of an established prognostic score-report of the Radiation Oncology Group (ROG) of the German Cancer Consortium (DKTK). Cancer Med 2018;7:1742-1749 (Pubmed-Link).

De-Colle C, Menegakis A, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, Abu Jawad J, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Belka C, Ganswindt U, Pigorsch S, Combs SE, Lohaus F, Linge A, Krause M, Baumann M, Zips D; DKTK-ROG. SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy. Radiother Oncol 2018;194:143-155. (Pubmed-Link)

Fokas E, Fietkau R, Hartmann A, Hohenberger W, Grützmann R, Ghadimi M, Liersch T, Ströbel P, Grabenbauer GG, Graeven U, Hofheinz RD, Köhne CH, Wittekind C, Sauer R, Kaufmann M, Hothorn T, Rödel C. Neoadjuvant rectal score as individual-level surrogate for disease-free survival in rectal cancer in the CAO/ARO/AIO-04 randomized phase 3 trial. Ann Oncol 2018;29:1521-1527 (Pubmed-Link).

Förster S, Hehlgans S, Rödel F, Otto B, Cordes N. Radiochemosensitivity and invasion of human colorectal cancer cells is regulated in an α-catenin-independent manner. Int J Oncol 2018; 52:1117- 28 (Pubmed-Link).

Gani C, Bonomo P, Zwirner K, Schroeder C, Menegakis A, Rödel C, Zips D. Organ preservation in rectal cancer - Challenges and future strategies. Clin Transl Radiat Oncol 2017;3:9-15. (Pubmed-Link)

Gani C, Grosse U, Clasen S, Kirschniak A, Goetz M, Rödel C, Zips D. Cost analysis of a wait-and-see strategy after radiochemotherapy in distal rectal cancer. Strahlenther Onkol  2018; 194:985-990. (Pubmed-Link)

Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, Arnold D; ESMO Guidelines Committee. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2018;29 (Supplement_4):iv263 (Pubmed-Link)

Hecht M, Meier F, Zimmer L, Polat B, Loquai C, Weishaupt C, Forschner A, Gutzmer R, Utikal JS, Goldinger SM, Geier M, Hassel JC, Balermpas P, Kiecker F, Rauschenberg R, Dietrich U, Clemens P, Berking C, Grabenbauer G, Schadendorf D, Grabbe S, Schuler G, Fietkau R, Distel LV, Heinzerling L. Clinical outcome of concomitant vs interrupted BRAF inhibitor therapy during radiotherapy in melanoma patients. Br J Cancer 2018;118(6):785-792. (Pubmed-Link).

Hehlgans S, Booms P, Güllülü Ö, Sader R, Rödel C, Balermpas P, Rödel F ,Ghanaati S. Radiation sensitization of basal cell and head and neck squamous cell carcinoma by the Hedgehog pathway inhibitor vismodegib. Int J Mol Sci 2018;19:e2485 (Pubmed-Link).

Hofheinz RD, Arnold D, Fokas E, Kaufmann M, Hothorn T, Folprecht G, Fietkau R, Hohenberger W, Ghadimi M, Liersch T, Grabenbauer GG, Sauer R, Rödel C, Graeven U; German Rectal Cancer Study Group. Impact of age on the efficacy of oxaliplatin in the preoperative chemoradiotherapy and adjuvant chemotherapy of rectal cancer: A post hoc analysis of the CAO/ARO/AIO-04 phase 3 Trial. Ann Oncol 2018;29:1793-1799 (Pubmed-Link).

Karagiannis E, Leczynski A, Tselis N, Psanis E, Steckenreiter O, Milickovic N, Bon D, Strouthos I, Ferentinos K, Hass P, Gademann G, Baltas D, Zamboglou N. Inverse planning and inverse implanting for breast interstitial brachytherapy. Introducing a new anatomy specific breast interstitial template (ASBIT). Radiother Oncol 2018;128:421-427 (Pubmed-Link).

Kitz J*, Fokas E*, Beissbarth, Ströbel P, Wittekind C, Hartmann A, Rüschoff J, Papadopoulos T, Rösler E, Ortloff-Kittredge P, Kania U, Schlitt H, Link KH, Bechstein W, Raab HR, Staib L, Germer CT, Liersch T, Sauer R, Rödel C, Ghadimi M, Hohenberger W; German Rectal Cancer Study Group. Association of Plane of Total Mesorectal Excision With Prognosis of Rectal Cancer: Secondary Analysis of the CAO/ARO/AIO-04 Phase 3 Randomized Clinical Trial. JAMA Surgery 2018;53:e181607. *joint first authors (Pubmed-Link).

Klement RJ, Hoerner-Rieber J, Adebahr S, Andratschke N, Blanck O, Boda-Heggemann J, Duma M, Eble MJ, Eich HC, Flentje M, Gerum S, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl KH, Klass ND, Krempien R, Lohaus E, Petersen C, Schrade E, Wendt TG, Wittig A, Guckenberger M. Stereotactic body radiotherapy (SBRT) for multiple pulmonary oligometastases: Analysis of number and timing of repeat SBRT as impact factors on treatment safety and efficacy. Radiother Oncol 2018;127:246-252 (Pubmed-Link).

Linge A, Schötz U, Löck S, Lohaus F, Neubeck CV, Gudziol V, Nowak A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Lauber K, Pigorsch S, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Krause M, Belka C, Baumann M; DKTK-ROG. Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC. Radiother Oncol 2018;127:27-35 (Pubmed-Link).

Martin D, Balermpas P, Winkelmann R, Rödel F, Rödel C, Fokas E. Anal squamous cell carcinoma – State of the art management and future perspectives. Cancer Treat Rev 2018;65:11-21. (Pubmed-Link).

Martin D, Rödel C, Fokas E. Nivolumab for pretreated metastatic anal cancer : Immune checkpoint blockade is also advised in combination with radiochemotherapy. Strahlenther Onkol. 2018;194:356-57 (Pubmed-Link)

Müller von der Grün J, Bon D, Rödel C, Balermpas P. Patterns of care analysis for head & neck cancer of unknown primary site: a survey inside the German society of radiation oncology (DEGRO) Strahlenther Onkol 2018;94:750-758. (Pubmed-Link).

Müller von der Grün J, Martin D , Stöver T ,Ghanaati S, Rödel C, Balermpas P. Chemoradiotherapy as definitive treatment for elderly patients with head and neck cancer. Biomed Res Int 2018;e3508795 (PubMed-Link).

Moustakis C, Chan MKH, Kim J, Nilsson J, Bergman A, Bichay TJ, Palazon Cano I, Cilla S, Deodato F, Doro R, Dunst J, Eich HT, Fau P, Fong M, Haverkamp U, Heinze S, Hildebrandt G, Imhoff D, de Klerck E, Köhn J, Lambrecht U, Loutfi-Krauss B, Ebrahimi F, Masi L, Mayville AH, Mestrovic A, Milder M, Morganti AG, Rades D, Ramm U, Rödel C, Siebert FA, den Toom W, Wang L, Wurster S, Schweikard A, Soltys SG, Ryu S, Blanck O. Treatment planning for spinal radiosurgery : A competitive multiplatform benchmark challenge. Strahlenther Onkol 2018;194:843-854 (Pubmed-Link).

Murakami N, Ueno T, Yatsuoka W, Okamoto H, Tselis N, Masui K, Yoshida K, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami J. Dose coverage comparison between "interstitial catheter-only" and "hybrid intracavitary-interstitial brachytherapy" for early stage squamous cell carcinoma of the buccal mucosa. J Contemp Brachytherapy. 2018;10:486-491 (Pubmed-Link).

Niyazi M, Adeberg S, Kaul D, Boulesteix AL, Bougatf N, Fleischmann DF, Grün A, Krämer A, Rödel C, Eckert F, Paulsen F, Kessel KA, Combs SE, Oehlke O, Grosu AL, Seidlitz A, Lattermann A, Krause M, Baumann M, Guberina M, Stuschke M, Budach V, Belka C, Debus J. Independent validation of a new reirradiation risk score (RRRS) for glioma patients predicting post-recurrence survival: A multicenter DKTK/ROG analysis. Radiother Oncol 2018;127:121-127. (Pubmed-Link)

Rödel F, Steinhäuser K, Nina-Naomi Kreis NN, Friemel A, Martin D, Wieland U, Rave-Fränk M, Balermpas P, Fokas E, Louwen F, Claus Rödel C, Yuan J. Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy.  Radiother Oncol 2018;126:214-221 (Pubmed-Link).

Schmidt S, Linge A, Zwanenburg A, Leger S, Lohaus F, Krenn C, Appold S, Gudziol V, Nowak A, von Neubeck C, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch SU, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Baumann M, Krause M, Löck S. Development and validation of a gene signature for patients with head and neck squamous cell carcinomas treated by postoperative radio(chemo) therapy. Clin Cancer Res 2018;24:1364-1374. (Pubmed-Link)

Sprenger T, Beißbarth T, Sauer R, Tschmelitsch J, Fietkau R, Liersch T, Hohenberger W, Staib L, Gaedcke J, Raab HR, Rödel C, Ghadimi M. Long-term prognostic impact of surgical complications in the German Rectal Cancer Trial CAO/ARO/AIO-94. Long-term prognostic impact of surgical complications in the German Rectal Cancer Trial CAO/ARO/AIO-94.Br J Surg 2018;105:1510-1518 (Pubmed-Link).

Stangl S, Tontcheva N, Sievert W, Shevtsov M, Niu M, Pigorsch S, Combs S, Haller B, Balermpas P, Rödel F, Rödel C, Fokas E, Krause M, Linge A, Lohhaus F, Baumann M, Tinhofer I, Budach V, Stuschke M, Grosu AL, Abdollahi A, Debus J, Belka C, Lauber K, Mönnich D, Zips D, Multhoff G. Heat shock protein 70 expression and infiltration of CD56+ NK cells as prognostic indicators of survival in patients with squamous cell carcinoma of the head and neck cancer (SCCHN) after adjuvant radiochemotherapy: a multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Int J Cancer 2018;142:1911-25. (Pubmed-Link)

Stera S, Balermpas P, Chan MKH, Huttenlocher S, Wurster S, Keller C, Imhoff D, Rades D, Dunst J, Rödel C, Hildebrandt G, Blanck O. Breathing-motion-compensated robotic guided stereotactic body radiation therapy:Patterns of failure analysis. Strahlenther Onkol 2018;194:143-155 (Pubmed-Link).

Strouthos I, Tselis N, Chatzikonstantinou G, Butt S, Baltas D, Bon D, Milickovic N, Zamboglou N. High dose rate brachytherapy as monotherapy for localised prostate cancer. Radiother Oncol 2017; epub ahead of print. (Pubmed-Link)

Strouthos I, Chatzikonstantinou G, Zamboglou N, Milickovic N, Papaioannou S, Bon D, Zamboglou C, Rödel C, Baltas D, Tselis N. Combined high dose rate brachytherapy and external beam radiotherapy for clinically localised prostate cancer. Radiother Oncol 2018;126:270-277 (PubMed-Link).

Tselis N, Prott FJ, Ott O, Weiss C, Rödel C. Radiochemotherapy for invasive bladder cancer : An update. Urologe A. 2018;57:679-685 (Pubmed-Link).

Umezawa R, Murakami N, Nakamura S, Wakita A, Okamoto H, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Inaba K, Ito Y, Igaki H, Masui K, Yoshida K, Jingu K, Tselis N, Itami J. Image-guided interstitial high-dose-rate brachytherapy for locally recurrent uterine cervical cancer: A single-institution study. Brachytherapy 2017;17:368-376 (Pubmed-Link).

von den Grün J, Hartmann A, Fietkau R, Ghadimi M, Liersch T, Hohenberger W, Weitz J, Sauer R, Wittekind C, Ströbel P, Rödel C, Fokas E. Can clinicopathological parameters predict for lymph node metastases in ypT0-2 rectal carcinoma? Results of the CAO/ARO/AIO-94 and CAO/ARO/AIO-04 phase 3 trials. Radiother Oncol 2018;128:557-563 (Pubmed-Link).

Voos P, Fuck S, Weipert F, Babel L, Tandl D, Spahn A, Hehlgans S, Fournier C, Moronid A, Rödel F, Thiel G. Ionizing radiation induces morphological changes and immunological modulation of Jurkat cells. Front in Immunol 2018;9:922. (Pubmed-Link).

2017

Antonietti P, Linder B, Hehlgans S, Mildenberger I, Burger M, Fulda S, Steinbach J, Gessler F, Rödel F, Mittelbronn M, Kögel D. Interference with the HSF1/HSP70/BAG3 pathway primes glioma cells to matrix detachment and BH3 mimetic-induced apoptosis. Mol Cancer Ther 2017;16:156-168. (Pubmed-Link)

Al-Batran SE, Goetze TO, Mueller DW, Vogel A, Winkler M, Lorenzen S, Novotny A, Pauligk C, Homann N, Jungbluth T, Reissfelder C, Caca K, Retter S, Horndasch E, Gumpp J, Bolling C, Fuchs KH, Blau W, Padberg W, Pohl M, Wunsch A, Michl P, Mannes F, Schwarzbach M, Schmalenberg H, Hohaus M, Scholz C, Benckert C, Knorrenschild JR, Kanngießer V, Zander T, Alakus H, Hofheinz RD, Roedel C, Shah MA, Sasako M, Lorenz D, Izbicki J, Bechstein WO, Lang H, Moenig SP. The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction - a phase III trial of the German AIO/CAO-V/CAOGI. BMC Cancer. 2017 Dec 28;17(1):893 (Pubmed-Link)

Azad A, Yin Lim S, D'Costa Z, Jones K, Diana A, Sansom OJ, Kruger P, Liu S, McKenna WG, Dushek O, Muschel RJ, Fokas E. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Mol Med 2017;9(2):167-180. (Pubmed-Link)

Badawi A, Hehlgans S, Pfeilschifter J, Rödel F, Eberhardt W. Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. Cancer Letters 2017;393:103-112. (Pubmed-Link)

Balermpas P, Martin D, Wieland U, Rave-Fränk M, Strebhardt K, Rödel C, Fokas E, Rödel F. Human papilloma virus load and PD-1/PD-L1, CD8 and FOXP3 in anal cancer patients treated with chemo radiotherapy: Rationale for immunotherapy. Oncoimmunology 2017;6:e1288331. (PubMed-Link)

Balermpas P, Rödel F, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Sak A, Stuschke M, Gkika E, Grosu AL, Abdollahi A, Debus J, Stangl S, Ganswindt U, Belka C, Pigorsch S, Multhoff  G, Combs SE, Welz S, Zips D, Lim SY, Rödel C,  Fokas  E.  The PD-1/ PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradio- therapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Int J Cancer 2017;141:594-603. (Pubmed-Link).

Chatzikonstantinou G, Zamboglou N, Rödel C, Zoga E, Strouthos I, Butt SA, Tselis N. High-dose-rate brachytherapy as salvage modality for locally recurrent prostate cancer after definitive radiotherapy : A systematic review. Strahlenther Onkol 2017;193:683-691. (Pubmed-Link).

D'Costa Z, Jones K, Azad A, van Stiphout R, Lim SY, Gomes AL, Kinchesh P, Smart SC, McKenna WG, Buffa FM, Sansom OJ, Muschel RJ, O'Neill E, Fokas E. Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Cancer Res 2017;77:5952-962 (Pubmed-Link).

Erbeldinger N, Merz F, Ktitareva S, Wendel P, Bothe AS, Dettmering T, Durante M, Friedrich T, Bertulat B, Meyer S, M. Cardoso C, Hehlgans S, Rödel F, Fournier C. Measuring leukocyte adhesion to (primary) endothelial cells after photon and charged particle exposure with a dedicated laminar flow chamber. Frontiers in Immunol 2017;8:627. (Pubmed-Link).

Elsayad K, Kriz J, Seegenschmiedt H, Imhoff D, Heyd R, Eich HT, Micke O. Radiotherapy for aneurysmal bone cysts : A rare indication. Strahlenther Onkol 2017;193:332-240 (Pubmed-Link)

Fotouhi Ghiam A, Taeb S, Huang X, Huang V, Ray J, Scarcello S, Hoey C, Jahangiri S, Fokas E, Loblaw A, Bristow RG, Vesprini D, Boutros P, Liu SK. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer. Oncotarget 2017;8(3):4668-4689. (Pubmed-Link)

Fokas E, Ströbel P, Fietkau R, Ghadimi M, Liersch T, Grabenbauer GG, Hartmann A, Kaufmann M, Sauer R, Graeven U, Hoffmanns H, Raab HR, Hothorn T, Wittekind  C, Rödel C. Tumor regression grading after preoperative chemoradiotherapy as prognostic factor and individual-level surrogate for disease-free survival in rectal cancer. J Natl Cancer Inst 2017; Dec 109(12). (Pubmed-Link)

Frey B, Rückert M, Weber J, Mayr X, Derer A, Lotter M, Bert C, Rödel F, Fietkau R, Gaipl US. Hypofractionated irradiation has immune stimulatory potential and induces a timely restricted infiltration of immune cells in colon cancer tumors. Frontiers in Immunol 2017;8:231. (Pubmed-Link)

Gani C, Bonomo P, Zwirner K, Menegakis A, Rödel C, Zips D. Organ preservation in rectal cancer – Challenges and future strategies. Clinical and Translational Radiation Oncology 2017 (Pubmed-Link)

Gkika E., S. Tanadini-Lang S., S. Kirste, P. A. Holzner, H. P. Neeff, H. C. Rischke, T. Reese, F. Lohaus, M. N. Duma, K. Dieckmann, R. Semrau, M. Stockinger, D. Imhoff, N. Kremers, M. F. Häfner, N. Andratschke, U. Nestle, A. L. Grosu, M. Guckenberger, T. B. Brunner. Interobserver variability in target volume delineation of hepatocellular carcinoma. An analysis of the working group “Stereotactic Radiotherapy” of the German Society for Radiation Oncology (DEGRO). Strahlenther und Onkol 2017:193:823–830. (Pubmed-Link)

Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, Arnold D; ESMO Guidelines Committee. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2017;28(suppl_4):iv22-iv40. (Pubmed-Link).

Gordon-Weeks AN, Lim SY, Yuzhalin AE, Jones K, Markelc B, Buzelli JN, Fokas E, Cao Y, Smart S, Muschel R. Neutrophils Promote Hepatic Metastasis Growth Through fibroblast growth factor (FGF)2-dependent Angiogenesis. Hepatology 2017;65:9120-1935. (Pubmed-Link)

Hill MA, Thompson J, Kavanagh A, Tullis IDC, Newman RG, Prentice J, Beech J, Gilchrist S, Smart S, Fokas E, Vojnovic B. The Development of Technology for Effective Respiratory-Gated Irradiation Using an Image-Guided Small Animal Irradiator. Radiat Res 2017;188:247-263. (Pubmed-Link)

Hristova Y, Köhn J, Preuß S, Rödel C, Balermpas P. A clinical example of extreme dose exposure for an implanted cardioverter-defibrillator : Beyond the DEGRO Guidelines. Strahlenther Onkol. 2017; 193(9):756-760 (Pubmed-Link)

Jiang P, Krockenberger K, Vonthein R, Tereszczuk J, Schreiber A, Liebau S, Huttenlocher S, Imhoff D, Balermpas P, Keller C, Dellas K, Baumann R, Rödel C, Hildebrandt G, Jünemann KP, Merseburger AS, Katz A, Ziegler A, Blanck O, Dunst J. Hypo-fractionated SBRT for localized prostate cancer: a German bi-center single treatment group feasibility trial. Radiat Oncol 2017;12:138. (Pubmed-Link)

Kersemans V, Gomes AL, Beech JS, Gilchrist S, Kinchesh P, Allen PD, Thompson J, Bird L, Tullis IDC, Newman RG, Dulmont AC, Falzone N, Vallis KA, Azad A, D’Costa Z, Sansom OJ, Muschel RJ, Vojnovic B, Hill MA, Fokas E, Smart SC. MRI-guided Radiotherapy for Targeting Abdominal Organs in the Mouse with the Small Animal Radiation Research Platform (SARRP) PLOS One 2017;12:e0176693.(Pubmed-Link)

Köhn J, Licher J, Mielke M, Loutfi-Krauss B, Blümer N, Heine B, Rödel C, Scherf C, Ramm U. Image movement of the Elekta EPID during gantry rotation: Effects on the verification of dose distributions. Physica Medica 2017; S1120-1797(17)30026-1 (Pubmed-Link)

Leger S, Zwanenburg A, Pilz K, Lohaus F, Linge A, Zöphel K, Kotzerke J, Schreiber A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Krause M, Baumann M, Troost EGC, Löck S, Richter C. A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling. Sci Rep. 2017 Oct 16;7(1):13206 (Pubmed-Link)

Martin D, Rödel F, Winkelmann R, Balermpas P, Rödel C, Fokas E. Peripheral leukocytosis is inversely correlated with intratumoral CD8+ T-cell infiltration and associated with worse outcome after chemoradiotherapy in anal cancer. Front Immunol 2017:8;1225. (Pubmed-Link)

Martin D, Balermpas P, Fokas E, Rödel C, Yildirim M. Are there HIV-specific Differences for Anal Cancer Patients Treated with Standard Chemoradiotherapy in the Era of Combined Antiretroviral Therapy? Clin Oncol (R Coll Radiol) 2017;29:248-55. (Pubmed-Link)

Martin D, Rödel F, Balermpas P, Rödel C, Fokas E. The immune microenvironment and HPV in anal cancer: Rationale to complement chemoradiation with immunotherapy. BBA Reviews in Cancer 2017;1868(1):221-230. (Pubmed-Link)

Martin D, Rödel C, Fokas E. How long should we wait upon completion of chemoradiotherapy before assessment of tumor response in anal cancer? Strahlenther Onkol. 2017;193:593-594. (Pubmed-Link)

Mesci A, Huang X, Taeb S, Jahangiri S, Kim Y, Fokas E, Bruce J, Leong HS, Liu SK. Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis. Br J Cancer 2017;116:1350-1357. (Pubmed-Link)

Milickovic N, Tselis N, Karagiannis E, Ferentinos K, Zamboglou N. Iridium-Knife: Another knife in radiation oncology. Brachytherapy 201716:884-892. (Pubmed-Link).

Müller von der Grün J, Tahtali A, Ghanaati S, Rödel C, Balermpas P. Diagnostic and Treatment Modalities for Patients with Cervical Lymph Node Metastases of Unknown Primary Site - Current Status and Challenges. Radiation Oncology 2017;12:82. (Pubmed-Link)

Patel N, Able S,  Allen D, Fokas E, Cornelissen B, Gleeson FV, Harris AL, Vallis KA. Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab. EJNMMI Research 2017;7:49. (PubMed-Link)

Rieber J, Abbassi-Senger N, Adebahr S, Andratschke N, Blanck O, Duma M, Eble MJ, Ernst I, Flentje M, Gerum S, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl H, Klass ND, Krempien R, Lohaus F, Lohr F, Petersen C, Schrade E, Streblow J, Uhlmann L, Wittig A, Sterzing F, Guckenberger M. Influence of Institutional Experience and Technological Advances on Outcome of Stereotactic Body Radiation Therapy for Oligometastatic Lung Disease. Int J Radiat Oncol Biol Phys  2017;98:511-520. (PubMed-Link)

Rödel C, Fokas E. Inklusion von Oxaliplatin in die multimodale Behandlung des lokal fortge- schrittenen Rektumkarzinoms. Strahlenther Onkol 2017;193:168-170. (Pubmed-Link)

Rödel F, Fournier C, Wiedemann J, Merz F, Gaipl US, Frey B, Keilholz L, Seegenschmiedt MH, Rödel C, Hehlgans S. Basics of radiation biology when treating hyperproliferative benign diseases. Frontiers in Immunol 2017;8:519. (Pubmed-Link)

Schmiegel W, Buchberger B, Follmann M, Graeven U, Heinemann V, Langer T, Nothacker M, Porschen R, Rödel C, Rösch T, Schmitt W, Wesselmann S, Pox C. S3-Leitlinie – Kolorektales Karzinom. Z Gastroenterol 2017;55:1344-1498. (Pubmed-Link)

Strouthos I, Chatzikonstantinou G, Tselis N, Bon D, Karagiannis E, Zoga E, Ferentinos K, Maximenko J, Nikolettou-Fischer V, Zamboglou N. Photobiomodulation therapy for the management of radiation-induced dermatitis : A single-institution experience of adjuvant radiotherapy in breast cancer patients after breast conserving surgery. Strahlenther Onkol 2017;193:491-498. (Pubmed-Link)

Tanadini-Langa S,  Rieber J, Filippi AR, Fode MM, Streblow J, Adebahr S, N. Andratschke N, Blanck O, Boda-Heggemann J, Duma M, Eble MJ, Ernst I, Flentje M, Gerum S, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl H, Klass ND, Krempien R, Lohaus F, Petersen C, Schrade E, Wendt TG, Wittig A, Høyer M, Ricardi U, Sterzing F, Guckenberger M. Nomogram based overall survival prediction in stereotactic body radiotherapy for oligo-metastatic lung disease. Radiother Oncol 2017;123:182-188. (Pubmed-Link)

Tselis N, Karagiannis E, Kolotas C, Baghi M, Milickovic N, Zamboglou N. Image-guided interstitial high-dose-rate brachytherapy in the treatment of inoperable recurrent head and neck malignancies: An effective option of reirradiation. Head Neck 2017;39:E61-E68. (Pubmed-Link)

Tselis N, Hoskin P, Baltas D, Strnad V, Zamboglou N, Rödel C, Chatzikonstantinou G. High Dose Rate Brachytherapy as Monotherapy for Localised Prostate Cancer: Review of the Current Status. Clin Oncol (R Coll Radiol), 2017;29:401-411. (Pubmed-Link)

Wagner J, Pfannenstiel V, Waldmann A, Bergs WJ, Brill B, Hünecke S, Klingebiel T, Rödel F, Buchholz C, Wels W, Peter Bader P, Evelyn Ullrich E.  A two-phase expansion protocol combining IL-15 and IL-21 improves NK cell proliferation and cytotoxicity against Rhabdomyosarcoma. Frontiers in Immunol 2017;8:676. (Pubmed-Link)

Wenger KJ, Wagner M, You SJ, Franz K, Harter PN, Burger MC, Voss M, Ronellenfitsch MW, Fokas E, Steinbach JP, Bähr O. Bevacizumab as a last-line treatment for glioblastoma following failure of radiotherapy, temozolomide and lomustine. Oncol Lett 2017;14:1141-1146. (Pubmed-Link).

Yildirim M, Müller von der Grün J, Winkelmann R, Fokas E, Rödel F, Ackermann H, Rödel C, Balermpas P. Combined p16 and p53 expression in cervical cancer of unknown primary (CUP) and other prognostic parameters: a single center analysis. Strahlenther Onkol 2017;193:305-314. (Pubmed-Link)

 

 

2016

Andratschke N, Parys A, Stadtfeld S, Wurster S, Huttenlocher S, Imhoff D, Yildirim M, Rades D, Rödel CM, Dunst J, Hildebrandt G, Blanck O. Clinical results of mean GTV dose optimized robotic guided SBRT for liver metastases Radiation Oncology 2016;11:74. (Pubmed-Link)

Ashton TM, Fokas E, Kunz-Schughart LA, Folkes LK, Anbalagan S, Huether M, Kelly CJ, Pirovano G, Buffa FM, Hammond EM, Stratford M, Muschel RJ, Higgins GS, McKenna WG. The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia. Nat Commun 2016;7:12308. (Pubmed-Link)

Azad A, Yin Lim S, D'Costa Z, Jones K, Diana A,  Sansom OJ, Kruger P, Liu S, McKenna WG, Dushek O, Muschel RJ, Fokas E. PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Molecular Medicine 2016;9(2):167-180. (Pubmed-Link)

Balermpas P, Rödel F, Rödel C, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Gkika E, Stuschke M, Avlar M, Grosu AL, Abdollahi A, Debus J, Bayer C, Stangl S, Belka C, Pigorsch S, Multhoff G, Combs SE, Mönnich D, Zips D, Fokas E; DKTK-ROG. CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Int J Cancer 2016;138:171-81. (Pubmed-Link)

Bertz S, Wach S, Taubert H, Merten R, Krause FS, Schick S, Ott OJ, Weigert E, Dworak O, Rödel C, Fietkau R, Wullich B, Keck B, Hartmann A. Micropapillary morphology is an indicator of poor prognosis in patients with urothelial carcinoma treated with transurethral resection and radiochemotherapy. Virchows Arch 2016;469:339-44. (Pubmed-Link)

Blanck O, Wang L, Baus W, Grimm J, Lacornerie T, Nilsson J, Luchkovskyi S, Palazon Cano I, Shou Z, Ayadi M, Treuer H, Viard R, Siebert FA, Chan MK, Hildebrandt G, Dunst J, Imhoff D, Wurster S, Wolff R, Romanelli P, Lartigau E, Semrau R, Soltys SG, Schweikard A. Inverse treatment planning for spinal robotic radiosurgery: an international multi-institutional benchmark trial. J Appl Clin Med Phys 2016;17:6151. (Pubmed-Link)

Blanck